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These challenges provide clear directions for subsequent translational strategies [78]

The Role of Vitamin E and Oxidative Stress in Diabetes Complications

Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes

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The ortho-phenolic hydroxyl group in phenolic compounds easily oxidizes to form a quinone structure, which is effective at neutralizing free radicals, especially ROS [15], through its ability to scavenge free radicals via various mechanisms, including single electron transfer, hydrogen atom transfer, and metal chelation [1, 2]